Inhibition of Herpesvirus Deoxyribonucleic Acid and Protein Synthesis by Tilorone Hydrochloride
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Inhibition of herpesvirus deoxyribonucleic acid and protein synthesis by tilorone hydrochloride.
Tilorone hydrochloride at a concentration of 10 mug/ml very efficiently inhibited herpes simplex virus growth in BSC1 cells when the virus is infected at a low multiplicity of infection. The adsorption of the virus was not affected by the drug, and the penetration of the deoxyribonucleic acid of the input virus into the cytoplasm and nuclei proceeded normally when tilorone hydrochloride was pre...
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MISSOURI The enzymatic synthesis of DNA1 in sufficient excess over the DNA used to prime the reaction21 a has enabled us to examine the chemical composition of the synthetic product. As has already been demonstrated, this DNA consists of deoxy-nucleotides Linked by typical 3'-5' phosphodiester bonds, and all four of the deoxy
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* Report of work supported by the U.S. Public Health Service, grants no. RG-3977, RG-5143, and A-3102. We wish to acknowledge the fine technical assistance of Hedi Imfeld and the counsel and cooperation of F. William Studier. 1 Huang, R. C., N. Maheshwari, and J. Bonner, Biochem. Biophys. Res. Comm., 3, 689 (1960). 2 Bonner, J., R. C. Huang, and N. Maheshwari, these PROCEEDINGS, 47, 1548 (1961)...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1976
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.9.1.189